The recently recognized immunodeficiency syndrome of idiopathic CD4+ T-lymphocytopenia was defined by the Centers for Disease Control and Prevention(CDC) to include depressed numbers of circulating CD4+ T-lymphocytes (<300 cells/㎣ or <20% of
total
T
cells) on more than one occasion. No laboratory evidence of infection with human immunodeficiency virus type 1(HIV-1) or type 2 (HIV-2), and the absence of any defined immunodeficiency or therapy associated with depressed levels of CD4+ T cells.
We had experienced one case of Idiopathic CD4+ T-lymphocytopenia without HIV infection, combined with Kaposi's sarcoma and Pneumocysis carinii pneumonia. She had visited to emergency room due to moderate dyspnea and fever for about three months.
On
physical examination, multiple purple colored mass lesions were detected on lower back. Both upper and lower extremities and right tonsillar area. Skin biopsy on mass of right lower extremity revealed Kaposi's sarcoma. On HRCT of the chest, patch
bilateral, symmetric reticulonodular infiltration were founded. So, we performed sputum cytology repeatedly, we identified pneumocystis carinii cysts.
Idiopathic CD4+ T-lymphocytopenia is rare and represents various clinical and immunologic states. It is perhaps more important to work harder to track the epidemiologic feature of this syndrome closely, to define the associated immune deficits
carefully, and to search broadly for the cause. Further epidemiologic, immunologic, and virologic studies will and in the characterization of this newly recognized condition.
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